Distinguishing rheumatoid arthritis from psoriatic arthritis - RMD …
Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) have key differences in clinical presentation, radiographic findings, comorbidities and pathogenesis to distinguish between these common forms of chronic inflammatory arthritis. Joint involvement is typically, but not always, asymmetric in PsA, while it is predominantly symmetric in RA. …
Homepage | RMD Open | A leading rheumatology journal from …
RMD Open publishes high quality peer-reviewed original research covering the full spectrum of musculoskeletal disorders, rheumatism and connective tissue diseases, including osteoporosis, spine and rehabilitation.Clinical and epidemiological research, basic and translational medicine, interesting clinical cases, and smaller studies that add to the literature are all considered.
Glucocorticoid-induced osteoporosis - RMD Open
Introduction. Glucocorticoid-induced osteoporosis (GIOP) is the most common cause of secondary osteoporosis, the first cause before 50 years and the first iatrogenic cause of the disease.1 Prior and current exposure to glucocorticoids (GCs) increases the risk of fracture and bone loss. A key point is that the underlying inflammation for which GCs are used also has a role in bone fragility, as ...
VEXAS syndrome: a diagnostic puzzle - RMD Open
The VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is an adult-onset systemic autoinflammatory condition that is caused by an acquired deficiency of the UBA1 gene in hematopoietic progenitor cells. The clinical spectrum of the VEXAS syndrome currently comprises a broad range of phenotypes such as vasculitis, relapsing polychondritis and Sweet’s syndrome. In the ...
The osteocyte: key player in regulating bone turnover - RMD Open
Throughout postnatal life bone undergoes continuous structural reorganisation and adaptation. The adaptive process is dependent on the coordinated activity of osteoclasts and osteoblasts that form a so called bone multicellular unit (BMU) that remodels cortical and trabecular bone through a process of osteoclast-mediated bone resorption, followed by …
Recommendations for physical activity and exercise in persons …
Objective This international task force aimed to provide healthcare professionals and persons living with systemic lupus erythematosus (SLE) with consensus-based recommendations for physical activity and exercise in SLE. Methods Based on evidence from a systematic literature review and expert opinion, 3 overarching principles and 15 recommendations were agreed on by Delphi consensus. Results ...
Li SWS, et al. RMD Open 20239:e003688 doi:101136rmdopen-2023-003688 1 REVIEW Treatment and monitoring of SAPHO syndrome: a systematic review Sophie W S Li,1 Eve Roberts,1 Christian Hedrich 1,2 To cite: Li SWS, Roberts E, Hedrich C. Treatment and monitoring of SAPHO syndrome:
Post-traumatic arthritis: overview on pathogenic mechanisms and …
Post-traumatic arthritis (PTA) develops after an acute direct trauma to the joints. PTA causes about 12% of all osteoarthritis cases, and a history of physical trauma may also be found in patients with chronic inflammatory arthritis. Symptoms include swelling, synovial effusion, pain and sometimes intra-articular bleeding. Usually, PTA recoveries spontaneously, but the persistence of symptoms ...
Biologicals in rheumatoid arthritis: current and future - RMD Open
The aim of the review is to highlight the current knowledge about established and new biologicals and to summarise recent advances by focusing on comparative efficacy, safety and possible discontinuation of treatment in patients with rheumatoid arthritis (RA). Up to now, comparative analyses showed only minor differences with respect …
EULAR/ACR classification criteria for adult and juvenile idiopathic ...
Objective To describe the methodology used to develop new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIMs) and their major subgroups. Methods An international, multidisciplinary group of myositis experts produced a set of 93 potentially relevant variables to be tested for inclusion in the criteria. Rheumatology, dermatology, neurology …